Fig. 7
From: Tyrosinase in melanoma inhibits anti-tumor activity of PD-1 deficient T cells
Schematic diagram. In tyrosinase-sufficient Tyr+/+ tumors, Pdcd1−/− mice exhibit a tumor weight comparable to that of B6 WT mice. There are no significant changes in T-cell infiltration or Tregs expression in the tumors of either B6 WT or Pdcd1−/− mice. The absence of tyrosinase in B16 melanoma enhances the anti-tumor activity of PD-1 deficient T cells. In tyrosinase-deficient Tyr−/− tumor, the tumor weight is significantly reduced in Pdcd1−/− mice compared to the B6 WT controls. This reduction is associated with a significant increase in T-cell infiltration and a decrease in Treg frequencies in the Pdcd1−/− mice