A comprehensive evaluation of diversity measures for TCR repertoire profiling

Table 2 Effect size (RBCC) of a difference between case–control groups. The closer the RBCC is to 1, the bigger the difference between the groups. Statistically significant comparisons (p-val < 0.05) are shown in bold and italics. *Sherwood_2015 is not a case–control study and for Ostmeyer_2020 there is no clinical data provided, thus no statistical testing was performed in these two cases

Method	S	Chao1	ACE	Shannon	Inv Simpson	Gini Simpson	D3	D4	Pielou	Basharin	d50	Gini
MEDI 2023 [25]	0.072	0.014	0.000	0.083	0.033	0.033	0.047	0.047	0.007	0.000	0.014	0.007
Huuhtanen 2022 [26]	0.206	0.029	0.147	0.265	0.618	0.618	0.647	*0.676*	0.441	0.441	0.294	0.324
Heikkila 2021 [27]	*1.000*	*1.000*	*0.875*	*1.000*	*1.000*	*1.000*	*1.000*	*1.000*	0.250	0.313	0.063	0.063
Emerson 2017_v3 [28]	0.092	0.016	0.021	*0.424*	*0.602*	*0.602*	*0.603*	*0.596*	*0.502*	*0.482*	*0.307*	*0.319*
Pruessmann 2020 [29]	0.043	0.043	0.043	0.055	0.027	0.027	0.023	0.011	0.027	0.023	0.022	0.032
Emerson 2017_v2 [28]	0.025	0.025	0.025	*0.159*	*0.212*	*0.212*	*0.198*	*0.192*	*0.219*	*0.216*	*0.181*	*0.171*
Emerson 2017_v1 [28]	0.245	0.245	0.245	*0.526*	*0.550*	*0.550*	*0.528*	*0.512*	*0.539*	*0.531*	*0.443*	*0.340*
Emerson 2013 [30]	*0.565*	*0.565*	*0.565*	*0.756*	*0.867*	*0.867*	*0.877*	*0.874*	*0.752*	*0.749*	*0.579*	*0.553*
Dean 2015 [31]	*0.144*	*0.144*	*0.144*	*0.138*	0.082	0.082	0.074	0.072	0.092	0.092	0.088	0.089
Robins 2015 [33]	0.074	0.074	0.074	0.015	0.088	0.088	0.191	0.250	0.088	0.088	0.103	0.176
Kuhs 2018_2 [34]	*0.520*	*0.520*	*0.520*	0.291	0.094	0.094	0.077	0.073	0.103	0.103	0.089	0.170
Kuhs 2018_1 [34]	*0.551*	*0.551*	*0.551*	0.251	0.025	0.025	0.027	0.020	0.068	0.068	0.056	0.146

ISSN: 1741-7007