A comprehensive evaluation of diversity measures for TCR repertoire profiling

Table 1 Description of analyzed real-world datasets

	Dataset	Annotation tool	Version	Sample type	Biological condition	N	Outliers
1	MEDI_2022 [25]	ImmunoSEQ	v4	Blood	Breast cancer chemotherapy response (pCR versus RD)	48	1
2	Huuhtanen_2022 [26]	ImmunoSEQ	v3	Blood	Prior Treatment vs No Prior Treatment	21	0
3	Heikkila_2021 [27]	ImmunoSEQ	v3	Blood and thymus tissue	Blood vs Thymus	12	0
4	Emerson_2017_v3[28]	ImmunoSEQ	v3	Blood	CMV + vs CMV −	119	0
5	Pruessmann_2020 [29]	ImmunoSEQ	v2	FFPE tissue blocks	Male vs Female	199	15
6	Emerson_2017_v2[28]	ImmunoSEQ	v2	Blood	CMV + vs CMV −	567	1
7	Emerson_2017_v1[28]	ImmunoSEQ	v1	Blood	CMV + vs CMV −	74	0
8	Emerson_2013 [30]	ImmunoSEQ	v1	Blood	CD4 vs CD8	118	3
9	Dean_2015 [31]	ImmunoSEQ	v1	Blood	Male vs Female	564	4
10	Sherwood_2015 [32]	ImmunoSEQ	v1	Blood	-	39	0
11	Robins_2015 [33]	ImmunoSEQ	v1	Blood	Male vs Female	26	1
12	Kuhs_2018_2 [34]	ImmunoSEQ	v1	Blood	HPV infection vs no HPV infection	60	2
13	Kuhs_2018_1 [34]	IgBlast	-	Blood	HPV infection vs no HPV infection	60	2
14	Ostmeyer_2020 [35]	IgBlast	-	FFPE tissue blocks	-	60	0

ISSN: 1741-7007