Fig. 2

Transcriptomic enrichment of oxytosis/ferroptosis in mouse models and human AD. A Enrichment of the FerrDb, TrioSig, Ferroptosis, Apoptosis, Necroptosis, and Autophagy signatures in transcriptomic data (DE genes between control and disease) of several brain regions from hAβ-KI, APP/PS1, 3xTg-AD, and 5xFAD mouse models of AD. HP, hippocampus; RS CX, retrosplenial cortex; ICX, insular cortex; HB, hemibrain. B Enrichment of the FerrDb, TrioSig, Ferroptosis, Apoptosis, Necroptosis, and Autophagy signatures in transcriptomic data (DE genes between control and AD) of several brain regions from human AD patients. CBE, cerebellum; TCX, temporal cortex; DLPFC, dorsolateral prefrontal cortex; ACC, anterior cingulate cortex; PCC, posterior cingulate cortex; FP, frontal pole; IFG, inferior frontal gyrus; PHG, parahippocampal gyrus; STG, superior temporal gyrus; HP, hippocampus; DG, dentate gyrus; CA, cornu ammonis. All DE genes together as well as separated by direction of expression (Down and Up) were analyzed. C Enrichment of the FerrDb, TrioSig, Ferroptosis, Apoptosis, Necroptosis, and Autophagy signatures in a nominated list of genes that may be good targets for new AD treatments or prevention (Agora)