Fig. 5

PTBP1 is simultaneously upregulated with circRNAs in AML and associated with poor prognosis. A Violin plot demonstrates the PTBP1 expression levels in healthy and AML samples. RNA-seq data for healthy and AML tissues were obtained from GSE158596. B Kaplan–Meier analysis of overall survival for AML patients with PTBP1 from TCGA and TARGET database. Red and blue curves represent the survival of AML patients with higher and lower PTBP1 expression levels, respectively. HR, hazard ratio. C Boxplot shows the expression levels of all circRNAs in healthy and AML samples. D Density scatter plot reflects the correlation of fold change of expression levels from circRNAs and the corresponding linear transcripts identified in AML versus healthy samples. E CircSPPL3 expression levels in healthy and AML samples. F Junction ratio of circRNAs in AML calculated by CIRIquant software