iPiDA-LGE: a local and global graph ensemble learning framework for identifying piRNA-disease associations

Table 3 The top five piRNAs associated with different diseases predicted by iPiDA-LGE

Disease	Rank	piRNA^a	Expression	Evidence^b
Parkinson’s disease	1	piR-hsa-28421	Downregulated	29986767
	2	piR-hsa-6841	Downregulated	29986767
	3	piR-hsa-183	Downregulated	29986767
	4	piR-hsa-16796	Downregulated	29986767
	5	piR-hsa-859	Downregulated	29986767
Cardiovascular disease	1	piR-hsa-4946	Downregulated	27131603
	2	piR-hsa-28185	Downregulated	27131603
	3	piR-hsa-27715	Downregulated	27131603
	4	piR-hsa-2219	Downregulated	27131603
	5	piR-hsa-27854	Downregulated	27131603
Renal cell carcinoma	1	piR-hsa-26731	Downregulated	26071182
	2	piR-hsa-27910	Upregulated	26071182
	3	piR-hsa-15980	Upregulated	26071182
	4	piR-hsa-31522	Downregulated	26071182
	5	piR-hsa-20294	Upregulated	26071182
Alzheimer disease	1	piR-hsa-25783	Upregulated	28127595
	2	piR-hsa-27438	Upregulated	28654860
	3	piR-hsa-27622	Upregulated	28127595
	4	piR-hsa-1100	Upregulated	26934981
	5	piR-hsa-16724	Downregulated	28654860
Male infertility	1	piR-hsa-32046	Downregulated	27068805
	2	piR-hsa-7144	Downregulated	27068805
	3	piR-hsa-7264	Downregulated	27068805
	4	piR-hsa-18608	Downregulated	27068805
	5	piR-hsa-18727	Downregulated	27068805

ISSN: 1741-7007