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Fig. 7 | BMC Biology

Fig. 7

From: Dysregulated lipid metabolism in a retinal pigment epithelial cell model and serum of patients with age-related macular degeneration

Fig. 7

Box plots of lipids showing statistical significance (adjusted p value < 0.05) between control (n = 20) subjects and AMD (n = 20) patients. Statistical significance was calculated through Mann–Whitney [GlcCer(d16:1/18:0), PE(19:1(9Z)/22:2(13Z,16)), and PC(22:2(13Z,16Z)/13:0)] or unpaired t-test [PE(15:0/20:3/5Z,8Z,11Z)] with Benjamini–Hochberg multiple testing correction and is shown in the graphs as asterisks (*: adjusted p value < 0.05; **: adjusted p value < 0.01; ***: adjusted p value < 0.001). Regulation of the same metabolites in the RPE cell cultures is shown as the comparison between 4 (n = 3 biological replicates, each measured 3 times) and 25 weeks (n = 3 biological replicates, each measured 3 times) in culture below each graph (see Additional file 4 for individual data values)

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BMC Biology

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