Fig. 4
From: Rare but specific: 5-bp composite motifs define SMAD binding in BMP signaling
5-bp spaced SMAD motifs are active across different tissues: a Schematic overview of publicly available SMAD1, SMAD1/5, or pSMAD1/5 ChIP-Seq datasets and ATAC-Seq data from a variety of cell types and stimulations extracted from ChIP-Atlas (52). b Absolute number of SMAD1-bound regions positive for 5-bp spaced SMAD homo-/heterocomposite motifs. c Genome browser view highlighting selected SMAD1-bound regions positive for SMAD composite motifs. d Percentage distribution of “SMAD composite motif”-positive SMAD1-bound regions in functional genomic regions according to Homer gene annotation. Percentages are normalized over the genomic abundance of each functional region. e Position weight matrices generated with DNAlogo 4.0 using all identified SMAD composite motifs reveal enriched linker sequences