Fig. 2

Dynamics of CTCF activity and recombination during meiosis. CTCF activity is visualised in the scRNA-seq (A) and scATAC-seq data (B), using the same embeddings as in Fig. 1. C CTCF binding-site footprinting profiles derived from the scATAC-seq data, using Signac [35]. Cell-type-specific peaks were profiled for ssDNA overlap (D) as well as paternal cross-over activity (E), using the genomation package in R [43]. F The 80% reciprocal overlap percentage for all scATAC-seq peaks in a given cell type versus ssDNA HSs (green) and paternal CO hotspots (purple)