Fig. 7

Psi Score as a biomarker for treatment response in CRC. A Psi Score change in CRC cells treated with 2.5 mM metformin (GSE171478) and under nutrient-rich and nutrient-depleted conditions (GSE245402). Differences between two groups are tested using two-tailed paired t test and considered p < 0.05 as statistical significance. B The correlation between Psi Score and drug sensitivity evaluated by the Spearman analysis. Each column represents a drug. The brightness of the column indicates the significance of the correlation. The height of the column indicates the correlation, indicates that Psi Score related to drug resistance (Rs > 0) or drug sensitive (Rs < 0) to Psi Score. C Signaling pathways targeted by drugs that are resistant or sensitivity to the Psi Score. Drug names are listed on the horizontal axis and the signaling pathway targeted by the drug on the vertical axis. The bar graph on the right shows the number of drugs targeting each signaling pathway. The size of the point indicates the significance of the correlation