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Fig. 8 | BMC Biology

Fig. 8

From: Rapid and high-throughput screening of proteolysis targeting chimeras using a dual-reporter system expressing fluorescence protein and luciferase

Fig. 8

SIRT2-PROTACs inhibited deacetylation and improved cytotoxicity. Three independent biological replicates were performed (n = 3). A and B The acetylation level of α-tubulin after treatment with compounds 128, 129, and TM at concentrations ranging from 0.01 to 10 µM for 6 h. C The antiproliferative effect of compounds 128, 129, TM, and LENA against MCF-7 cells treated for 72 h (mean ± SD from three independent experiments)

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BMC Biology

ISSN: 1741-7007

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