Fig. 7
From: CDK1 mediates the metabolic regulation of DNA double-strand break repair in metaphase II oocytes
CDK1 regulates polymerase theta-mediated end joining in MII oocytes. A POLQ foci can be found in DMEM-cultured MII oocytes but not in M2-cultured oocytes. Statistics performed by Fisher’s exact test. B POLQ focus formation in MII oocytes can be promoted by adding the CDK1 inhibitor RO-3306 or glucose + pyruvate + FBS (G.P.F.) to M2 media. Statistics performed by Fisher’s exact test. Scale bar, 5 μm. Significance markers: **, p < 0.01; ns, p > 0.05. Repeat number and sample size are indicated by the number of dots in the dot plots