Fig. 8

Model for MOV10 regulating access of AGO2 to the Numa1 mRNA in neurons where NUMA1 and HAUS polymerize microtubules for normal dendritic branching. Numa1 mRNA is translated into NUMA1. MOV10 binds the RNA G-quadruplex in the 3’UTR to prevent AGO2 from suppressing translation. NUMA1 and HAUS bind microtubules (green and yellow structures) to facilitate dendritogenesis. The asterisk indicates acetylation. In the absence of MOV10 (shown below), AGO2 accesses the MREs in the 3’UTR of the Numa1 mRNA leading to translation suppression (downward red arrow) and subsequent degradation of the mRNA. In the absence of NUMA1, unregulated HAUS complex facilitates increased polymerization (thick red arrows) of microtubules