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Fig. 2 | BMC Biology

Fig. 2

From: Effects of genetic ablation and pharmacological inhibition of HuR on gene expression, iron metabolism, and hormone levels

Fig. 2

Eltrombopag’s impact on the transcriptome is independent of HuR. Volcano plots illustrating differentially expressed (DE) genes (padj < 0.05 and fold change ± 2) in A HuR KO, B WT treatment with Eltrombopag, and C HuR KO treatment with Eltrombopag, accompanied by corresponding principal components plots (D, E, F). Upregulated genes are denoted in blue, while downregulated genes are indicated in red. G Up and downregulated genes across the three comparisons using Euler diagrams along with respective AREs. Upregulated AREs are indicated in light blue and downregulated AREs are denoted in light red. The overlap between H upregulated mRNAs and I downregulated mRNAs among the three comparisons

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BMC Biology

ISSN: 1741-7007

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