Fig. 5

In silico prediction of potential microbial pathways associated with interferon induction. A, B, D, E Percent of interferon non-stimulator (n = 25, purple) and stimulator (n = 33, green) genomes that contained a gene belonging to a given functional categories. Microbial genomes were annotated for A virulence factor functional categories (VFDB) and B secondary metabolite categories (antiSMASH). NRPS = non-ribosomal peptide synthetase, PKS = polyketide synthase. C One-way hierarchical clustering of differential presence (red)/absence (blue) of KEGG orthologs in streptococcal genomes for ISG non-stimulators/stimulators (annotated in purple/green bar at top) or antibacterial strong vs weak stimulator (annotated in blue/orange bar at top). D Virulence factor annotations from Fig. 5A were subsetted for streptococcal genomes. E Secondary metabolite annotates from Fig. 5B were subsetted for only Streptococcal genomes