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Fig. 3 | BMC Biology

Fig. 3

From: High matrix stiffness accelerates migration of hepatocellular carcinoma cells through the integrin β1-Plectin-F-actin axis

Fig. 3

Correlation of plectin and integrin β1 expression in HCC tissues. A Gene correlation: Scatter plot and fitted line from Spearman correlation analysis between plectin and integrin β1 expression. Each point represents a sample, with gene expression on the X and Y axes. B Integrin β1 mRNA expression in samples from TCGA database in HCC and normal tissues. C The expression levels of integrin β1 were significantly increased in COL1A1High-LOXHigh TCGA-HCC tissues (n = 119) compared to those in COL1A1Low-LOX.Low TCGA-HCC tissues (n = 120). D Detection of integrin β1 mRNA levels in MHCC-97H and MHCC-97L cells under different ECM stiffness. E Western blot detection of integrin β1 protein levels in MHCC-97H and MHCC-97L cells under different ECM stiffness. Data are presented as mean ± SD; n = 3, *p < 0.05, ***p < 0.001

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BMC Biology

ISSN: 1741-7007

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