Table 2 Significant MFFLs comprising genes with differential expression in the pseudotime trajectory between neoplastic and OPC clusters and concurrent differential APA events
From: Unveiling cell-type-specific microRNA networks through alternative polyadenylation in glioblastoma
Cluster | MicroRNA(s) | Transcription factors/Target genes | Center node |
|---|---|---|---|
Neoplastic | MIR155, MIR203A, MIR21 | JUN, LOX, ITGB8, PTX3 | TF |
Neoplastic | MIR128-2, MIR129-1, MIR129-2, MIR140, MIR150, MIR155, MIR194-2, MIR223, MIR338, MIR494 | STAT1, FAM172A, IL6ST | TF |
Neoplastic | MIR101-1 | BACH1, KLF6, PEBP1, TGFBR1 | MicroRNA |
Neoplastic | MIR101-2 | BACH1, FOS, KLF6, PEBP1, WEE1, TGFBR1 | MicroRNA |
Neoplastic | MIR27A | AR, TP53,PEBP1 | MicroRNA |
Neoplastic | MIR143, MIR16-2, MIR27A, MIR21 | AR, PEBP1, F2R | TF |
Neoplastic | MIR214, MIR27A, MIR377 | TP53, PEBP1, YWHAG | TF |
OPC | MIR27A | AR, TP53,PEBP1, SMURF1 | MicroRNA |
OPC | MIR21 | JUN,ITGB8, PTX3 | TF |