Fig. 4

Neurotransmitters associated with the neural correlates of working memory. Cross-region spatial correlations of neurotransmitters with the neural correlates of 3-back task accuracy (A) and reaction time (B). The outermost ring shows the names and maps of 27 neurotransmitter receptors/transporters. The second circle displays the neurotransmitter values across 210 cerebral cortical regions derived from the Human Brainnetome Atlas. The third circle displays the cross-region Pearson’s correlation coefficients between these neurotransmitter maps and the neural correlates of working memory, with the red (blue) color indicating the positive (negative) correlation coefficients and the column height indicating the magnitude of correlation coefficients. The innermost ring displays the permutation-based statistical significance of the spatial correlations, i.e., − log₁₀(P), with the darker color indicating the lower P value; ^*P < 0.05, Bonferroni corrected. The t maps for the correlations between FCD and working memory performance lie in the center. Abbreviations: 5-HT, 5-hydroxytryptamine; CB1, cannabinoid type 1; D, dopamine; DAT, dopamine transporter; FDOPA, fluorodopa; GABAa, gamma-aminobutyric acid a; MOR, mu opioid receptor; NAT, noradrenaline transporter; SERT, serotonin transporter; VAChT, vesicular acetylcholine transporter; mGluR5, metabotropic glutamate type 5; FCD, functional connectivity density