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Table 2 Gene ontology analysis of the significantly dysregulated seminal vesicle fluid proteins identifying implicated biological processes

From: Paternal undernutrition and overnutrition modify semen composition and preimplantation embryo developmental kinetics in mice

Comparison

Biological process

GO term

# proteins

FDR

CD vs LPD

Negative regulation of peptidase activity

GO:0010466

3

0.16

Cell activation

GO:0001775

2

0.33

Intermediate filament organisation

GO:0045109

2

0.97

CD vs MD-LPD

Proteolysis

GO:0006508

6

0.08

Regulation of smooth muscle cell migration

GO:0014910

2

0.61

Negative regulation of plasminogen activation

GO:0010757

2

0.61

Metabolic process

GO:0008152

3

0.61

Peptide metabolic process

GO:0006518

2

0.61

Response to lipopolysaccharide

GO:0032496

3

0.61

Negative regulation of protein processing

GO:0010955

2

0.61

Regulation of immune system process

GO:0002682

2

0.61

Carbohydrate metabolic process

GO:0005975

3

0.61

Negative regulation of proteolysis

GO:0045861

2

0.99

CD vs WD

Learning or memory

GO:0007611

3

0.56

Modulation of age-related behavioural decline

GO:0090647

2

0.64

Metabolic process

GO:0008152

3

0.64

Response to hypoxia

GO:0001666

3

0.64

Carbohydrate metabolic process

GO:0005975

3

0.64

Regulation of immune system process

GO:0002682

2

0.64

Positive regulation of receptor-mediated endocytosis

GO:0048260

2

0.72

Response to cadmium ion

GO:0046686

2

0.78

Acute-phase response

GO:0006953

2

0.81

CD vs MD-WD

Negative regulation of calcium ion import

GO:0090281

2

0.59

Modulation of age-related behavioural decline

GO:0090647

2

0.59

Proteolysis

GO:0006508

4

0.59

Positive regulation of protein tyrosine kinase activity

GO:0061098

2

0.92

Response to cadmium ion

GO:0046686

2

0.92

  1. GO Terms were generated by using free-web based software, DAVID Bioinformatics Resources, with all significantly differentially expressed (padj < 0.05) seminal vesicle fluid proteins from each comparison used as input lists. Seminal vesicle fluid extracted from n = 6 males per group