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Fig. 1 | BMC Biology

Fig. 1

From: Hypoxia and Foxn1 alter the proteomic signature of dermal fibroblasts to redirect scarless wound healing to scar-forming skin wound healing in Foxn1−/− mice

Fig. 1

Scheme of the proteomic experiment. DFs collected from the Foxn1−/− (CBy. Cg-Foxn1 < nu > /cmdb) mice were cocultured with keratinocytes collected from Foxn1.+/+ (C57BL/6 J) mice. Keratinocytes seeded in inserts were transduced with adenovirus carrying Foxn1 (Ad-Foxn1) or control (Ad-GFP). Keratinocytes and DFs were cocultured under hypoxic (1% O2) or normoxic (21% O2) conditions (n = 3, 2 animals per experiment, total n = 6 animals). After 24 h of coculture, DFs and DFCM were collected separately and subjected to detailed mass spectrometry analysis (LC‒MS/MS)

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BMC Biology

ISSN: 1741-7007

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