Fig. 2

Proteins interacting with DElncRNAs are involved in the cellular functions associated with PE. A Flowchart for the construction of DElncRNA-protein interaction network. The rectangle indicates lncRNAs, the triangle indicates transcription factors, and the circle indicates proteins. Red indicates upregulated genes in EOSPE, blue indicates downregulated genes in EOSPE, and grey indicates genes with no significant change in EOSPE. B–D DElncRNA interactors are enriched with PE-related genes from literature (B); DElncRNA interactors are enriched with DEGs in EOSPE (C); DElncRNA interactors are enriched with transcription factors (D). The fraction variation was estimated using a bootstrapping method with 100 resamplings, and the p-value was calculated by a one-sided Fisher’s exact test. E The enriched KEGG pathways of DEGs in the network. F The enriched GO MF terms of DEGs in the network