Fig. 1

Differentially expressed lncRNAs (DElncRNAs) in the placentae of EOSPE patients. A The expression pattern of 383 DElncRNAs (237 downregulated and 146 upregulated) across 41 samples (9 EOSPE samples and 32 normal samples). The bars on top indicate 5 aspects of the subjects: (1) sample groups: EOSPE (red) and normal (navy blue); (2) blood pressure: systolic pressure (dark green) and diastolic pressure (blue); (3) age of the mother: purple; (4) gestation days (pink); (5) baby weight (red). B The relative expression levels of FLNB-AS1 (EOSPE n = 8, Normal n = 6, Student’s t test), MIR193BHG (EOSPE n = 8, Normal n = 9, Student’s t test), MYCNUT (EOSPE n = 7, Normal n = 8, Wilcoxon test), NAV2-AS4 (EOSPE n = 7, Normal n = 7, Student’s t test), and CYP1B1-AS1 (EOSPE n = 7, Normal n = 7, Student’s t test) measured by qRT-PCR. C The number of DElncRNAs significantly correlated with blood pressure. D Spearman’s correlation between blood pressure and the expression levels of FLNB-AS1, MIR193BHG, and MYCNUT based on RNA-seq data. Blue indicates systolic pressure, red indicates diastolic pressure, the circle indicates EOSPE samples, and the triangle indicates normal samples. TPM: transcripts per million. E The distribution of AUC between coding DEGs and DElncRNAs. The p-value was calculated using a two-sided Wilcoxon test. F The discrimination accuracy of FLNB-AS1, MIR193BHG, and MYCNUT