Fig. 7

Graphical summary. Schematic model for the impact of HRJDs on intestinal homeostasis. In aged wildtype midguts, ISCs over-proliferate, and their daughters fail to differentiate into mature ECs, resulting in an accumulation of mis-differentiated cells (esg⁺ large polyploid). HRJD expression in adult ISCs/EBs further enhances ISC proliferation but suppresses mis-differentiation likely through upregulation of JAK-STAT signaling, which results in successful maintenance of the gut barrier and an extension of organismal lifespan