Fig. 6

Schematic diagram illustrating relative isolation of DEGs compared to the clustering of SEGs: A as a linear sequences; B as a two dimensional loops and three dimensional folding: Lineage-specific promoter-enhancer activation is indicated by colours (ectoderm—green, mesoderm—pink). Ovals (ectoderm—green, mesoderm—magenta) denote distal regulatory regions, crossed ovals are closed (chromatin inaccessible) enhancers. Genes are coloured elongated rectangles, promoter regions / TSS are grey squares. The grey-coloured circles with an oval at the centre represent a presumed radius of activation of a regulatory element and include the promoter region / TSS of its target gene(s). They correspond to the connecting arcs in the sequential representation (A) but demonstrate that linearly far away may be nearby in 2D