Fig. 6.
From: A coarse-grained approach to model the dynamics of the actomyosin cortex
The model predicts the effect of integrin overexpression. A Snapshots of the system for two different values of E1 (green is G-actin, snapshot taken at the point of maximal value of occupancy in a oscillation). B Temporal evolution of total actin and myosin in the cortex for the two values of E1 tested. Dashed gray lines show the average levels of actin. C Mean fluorescent intensity of integrins in stress fibers of follicle cells in control and αPS1; βPS overexpression (labeled as gain of function (GOF)) conditions (N = 11 for each condition). D, E Confocal images of the basal surface of follicle cells for control (D) and GOF (E) conditions expressing the F-actin live marker Ubi-LifeActinGFP stained for anti-GFP (green) and anti-BPS integrin (red). Circles denote follicle cells with the highest (solid line) and the lowest (dashed line) levels of F-actin fluorescence. F Quantification of the dynamic changes of basal F-actin in three individual follicle cells for control (left) and GOF (right) conditions. G Basal F-actin average oscillation period for control and GOF conditions (N = 11 for each condition)