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Fig. 7 | BMC Biology

Fig. 7

From: A CRISPR toolbox for generating intersectional genetic mouse models for functional, molecular, and anatomical circuit mapping

Fig. 7

Electrophysiological characterization of CNO-DREADD mediated responses in noradrenergic locus coeruleus (LC) neurons from lines RR1(P), RR2(P), and RC::FPDi (P). A Representative wash-on responses of LC neurons from RR1(P) (n = 19 neurons), RR2(P) (n = 10 neurons), and RC::FPDi(P) (n = 10 neurons) lines in response to DREADD agonist CNO. B Membrane potentials of each LC neuron (pre-CNO vs post-CNO values). C Summary plots of absolute voltage change for each DREADD line tested following CNO treatment. (*p < 0.05; **p < 0.01)

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